Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention
نویسندگان
چکیده
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses. A correlation has been found between high densities of TLS and prolonged patient's survival in more than 10 different types of cancer. TLS can be regulated by the same set of chemokines and cytokines that orchestrate lymphoid organogenesis and by regulatory T cells. Thus, TLS offer a series of putative new targets that could be used to develop therapies aiming to increase the anti-tumor immune response.
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Research, FIRB grant (RBAP11H2R9 to AM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Conflict of interest. There are no conflicts of interest to declare. Author manuscripts have been peer reviewed and accepted for...
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